Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace

A compound of formula (II),

• the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein
• each n is an integer with value 0, 1 or 2 and when n is 0 then a direct bond is intended;
• each m is an integer with value 1 or 2;
• each X is independently N or CH;
• Q is C1-2alkyloxycarbonyl, hydroxycarbonyl or tetrahydropyranyloxyaminocarbonyl;
• R1 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C1-6alkylsulfonyl, C1-6alkylcarbonyl or mono- or di(C1-6alkyl)aminosulfonyl;
• R2 is hydrogen, hydroxy, amino, halo, C1-6alkyl, cyano, C2-6alkenyl, polyhaloC1-6alkyl, nitro, phenyl, C1-6alkylcarbonyl, hydroxycarbonyl, C1-6alkylcarbonylamino, C1-6alkyloxy, or mono- or di(C1-6alkyl)amino;
• R3 is hydrogen, halo, C1-6alkyl, or C1-6alkyloxy;
• and
• when R2 and R3 are on adjacent carbon atoms, they can form the bivalent radical:
• —O—CH2—O— (a-2);
• R4 is hydrogen, C1-6alkyl, C1-6alkyloxyC1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylmethyl, phenylC1-6alkyl;
• or
• when R2 is on the 7-position of the indolyl then R2 and R4 together can form the bivalent radical;
• —(CH2)2— (a-3), or
• —(CH2)3— (a-4).