US 8,476,287 B2 · 3-hydroxy-5-arylisothiazole derivative

Abstract

[Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of solving the problem] A compound of Formula (I): (where n is 0 to 2; p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is an aryl group which is optionally substituted with L or a heterocyclic group which is optionally substituted with L; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is O, S, —NR7—; and R1 to R7 are specific groups), a salt of the compound, or a solvate of the salt or the compound.

A compound of Formula (I):

where n is an integer of 1;
p is an integer of 0 to 4;
j is an integer of 0 to 3;
k is an integer of 0 to 2;
a ring A is a C6-14 aryl group which is optionally substituted with 1 to 5 L(s) or a 3- to 14-membered heterocyclic group which is optionally substituted with 1 to 5 L(s);
a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring;
X is an oxygen atom, a sulfur atom, or —NR7—;
R1 are independently a group arbitrarily selected from a halogen atom, a C1-6 alkyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C2-6 alkenyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C2-6 alkynyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C1-6 alkoxy group which is optionally substituted with 1 to 5 substituent(s) RI, and a cyano group;
R2 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-6 alkoxy group, or a cyano group;
R3, R4, R5, R6, and R7 are independently a group arbitrarily selected from a hydrogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C2-6 alkenyl group, and a C2-6 alkynyl group;
Ls are independently a halogen atom, —OH, a cyano group, a C1-10 alkyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C2-10 alkenyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C2-10 alkynyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C1-10 alkoxy group which is optionally substituted with 1 to 5 substituent(s) RI, a C1-10 alkenyloxy group which is optionally substituted with 1 to 5 substituent(s) RI, a C1-10 alkynyloxy group which is optionally substituted with 1 to 5 substituent(s) RI, an aryl group which is optionally substituted with 1 to 5 substituent(s) RII, a heterocyclic group which is optionally substituted with 1 to 5 substituent(s) RII, an aralkyl group which is optionally substituted with 1 to 5 substituent(s) RII, a heteroarylalkyl group which is optionally substituted with 1 to 5 substituent(s) RII, an aryloxy group which is optionally substituted with 1 to 5 substituent(s) RII, a heteroaryloxy group which is optionally substituted with 1 to 5 substituent(s) RII, a non-aromatic heterocyclic oxy group which is optionally substituted with 1 to 5 substituent(s) RII, an aralkyloxy group which is optionally substituted with 1 to 5 substituent(s) RII, a heteroarylalkyloxy group which is optionally substituted with 1 to 5 substituent(s) RII, —SH, a —S(O)iRa (i is an integer of 0 to 2) group, or a —NRbRc group;
Ra is a group arbitrarily selected from a C1-6 alkyl group and a halogenated C1-6 alkyl group;
Rb and Rc are independently a group arbitrarily selected from a hydrogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-7 alkanoyl group (the alkanoyl group is optionally substituted with —OH or a C1-6 alkoxy group), a C1-6 alkylsulfonyl group, an arylcarbonyl group, and a heterocyclic carbonyl group, where Rb and Rc optionally form together with a nitrogen atom to which Rb and Rc are bonded, a 3- to 8-membered cyclic group, where in the cyclic group, one carbon atom is optionally substituted with an atom arbitrarily selected from an oxygen atom, a sulfur atom, and a nitrogen atom (the nitrogen atom is optionally substituted with a C1-6 alkyl group which is optionally substituted with 1 to 5 substituent(s) RI) or with a carbonyl group, and the cyclic group is optionally further substituted with 1 to 5 substituent(s) RII;
where the substituents RI are optionally the same as or different from each other and are each a group arbitrarily selected from a halogen atom, —OH, a cyano group, a C1-6 alkoxy group (the C1-6 alkoxy group is optionally substituted with 1 to 5 halogen atom(s), 1 to 5 —OH, 1 to 5 C1-6 alkoxy group(s), 1 to 5 non-aromatic heterocyclic group(s) (the heterocyclic group is optionally substituted with a C1-6 alkyl group), 1 to 5-S(O)iRa (i is an integer of 0 to 2) group(s), 1 to 5 —SO2NRdRe group(s), 1 to 5 —CONRdRe group(s), or 1 to 5 —NRb1Rc1 group(s)), a —NRb1Rc1 group, and a non-aromatic heterocyclic oxy group;
the substituents RII are optionally the same as or different from each other and are each a group arbitrarily selected from the substituents RI and a C1-6 alkyl group (the C1-6 alkyl group is optionally substituted with 1 to 5 halogen atom(s), 1 to 5 —OH, 1 to 5 C1-6 alkoxy group(s), 1 to 5 —S(O)iRa (i is an integer of 0 to 2) group(s), 1 to 5 —SO2NRdRe group(s), 1 to 5 —CONRdRe group(s), or 1 to 5 —NRb1Rc1 group(s));
Rd and Re are independently a hydrogen atom or a C1-6 alkyl group;
Rb1 and Rc1 are independently a group arbitrarily selected from a hydrogen atom, a C1-6 alkyl group, a C2-7 alkanoyl group, and a C1-6 alkylsulfonyl group, where Rb1 and Rc1 optionally form together with a nitrogen atom to which Rb1 and Rc1 are bonded, a 3- to 8-membered cyclic group, where in the cyclic group, one carbon atom is optionally substituted with an atom arbitrarily selected from an oxygen atom, a sulfur atom, and a nitrogen atom (the nitrogen atom is optionally substituted with a C1-6 alkyl group) or with a carbonyl group,
or a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable solvate of the salt or a pharmaceutically acceptable solvate of the compound.

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3-hydroxy-5-arylisothiazole derivative

Life of this patent

3-hydroxy-5-arylisothiazole derivative

Life of this patent

Abstract

Claims36