Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
AssigneeVersi Group, LLC
InventorsKwen-Jen Chang, Peter J. Gengo, Kestutis P. Biciunas, Xin Ma, William Pendergast, Shyi-Tai Jan
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Abstract
Compositions and methods for treatment of a urinary tract dysfunction by administering to a subject in need of such treatment a pharmaceutical composition including a delta opioid receptor agonist in an amount effective to reduce the effects of the urinary tract dysfunction. The compositions may further include an additional active agent that is used to treat urinary tract dysfunctions, e.g., alpha-adrenergic agonists, anticholinergics, alpha-adrenergic antagonists and tricyclic antidepressants.
Claims8
A method for combating a urinary tract dysfunction in a subject in need thereof comprising administering to the subject an effective amount of a delta opioid receptor agonist to combat the urinary tract dysfunction, wherein the delta opioid receptor agonist has the formula:
- or a pharmaceutically acceptable salt or ester thereof, wherein the urinary tract dysfunction is urinary incontinence.
A method for reducing the effects of urinary tract dysfunctions in a subject in need thereof comprising:
- administering to the subject an effective amount of at least one delta opioid receptor agonist selected from the group consisting of:
- and pharmaceutically acceptable salts and esters thereof, wherein the urinary tract dysfunction is urinary incontinence.
Dependencies are inferred from the claim text.