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US 8,476,276 B2Granted
Pharmaceutical compositions based on kinin B2 receptor antagonists and corticosteroids, and their use
AssigneeIstituto Luso Farmaco D'Italia S.p.A.
InventorsSandro Giuliani, Carlo Alberto Maggi
Life of this patent
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Abstract
Disclosed are pharmaceutical compositions containing, as active ingredients, a mixture of a corticosteroid and a kinin B2 receptor antagonist. Said compositions have proved particularly effective, especially in the treatment of inflammatory disorders such as asthma, ophthalmic or dermatological disorders and, above all, as regards the joints, arthritis.
Claims18
A pharmaceutical composition comprising, a corticosteroid and a B2 kinin receptor antagonist, together with pharmaceutically acceptable carriers and excipients, wherein:
- a) the corticosteroid, either natural or synthetic, is selected from Cortisone, Hydrocortisone, Beclomethasone, Betamethasone, Budesonide, Dexamethasone, Flumethasone, Flunisolide, Fluocortone, Fluticasone, Methylprednisolone, Methylprednisone, Paramethasone, Prednisolone, and Triamcinolone;
- and
- b) the B2 kinin receptor antagonist is a compound of general formula (I):
- wherein
- R is hydrogen or methyl;
- W represents a single bond or an oxygen atom;
- n is 3 or 4;
- X is hydrogen or an amine group —NR1R2 wherein R1 and R2 are, independently from one another, hydrogen or a group selected from methyl, ethyl, n-propyl, and isopropyl;
- Y is a quaternary ammonium —NR3R4R5 wherein R3, R4 and R5, independently from one another, are methyl, ethyl, n-propyl, isopropyl, butyl, isobutyl or n-pentyl;
- A- is an anion formally derived from a pharmaceutically acceptable acid;
- and pharmaceutically acceptable salts, enantiomers and enantiomeric mixtures thereof.
8 more elements
Dependencies are inferred from the claim text.