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US 8,476,273 B2Granted
Small molecule inhibitors of Lck SH2 domain binding
AssigneeUniversity of Maryland, Baltimore
InventorsJun Hayashi, Alexander Mackerell, Younus Mia, Guanjun Xia
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Abstract
The present invention provides materials and methods for modulating an immune response. The materials and methods may be used to treat diseases associated with an aberrant immune response. In some embodiments, materials and methods of the invention may be used to treat autoimmune diseases, for example, rheumatoid arthritis.
Claims5
A method of modulating the activity of Lck kinase in a patient in need thereof, comprising:
- administering to the patient an effective amount of a compound selected from the group consisting of compounds
Dependencies are inferred from the claim text.