Diazonamide analogs

A compound having the formula (V):

• or a pharmaceutically acceptable salt or conjugate thereof;
• wherein R1 is H, or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C5-C6 aryl, C6-C12 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted;
• R2 is H, or C1-C8 alkyl, C1-C8 heteroalkyl, C6-C14 arylalkyl, C6-C14 heteroarylalkyl, each of which may be optionally substituted;
• or
• R1 and R2 may be taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member;
• R8 and R9 are independently H, halo, or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C6-C12 aryl, C5-C12 heteroaryl, each of which may be optionally substituted, or COOR11 or CONR112, where each R11 is independently H or C1-C4 alkyl;
• m and m″ are independently 0-3;
• and
• each Y and Y″ is independently halo, OH, C1-C4 alkoxy, or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C12 aryl, or C6-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted;
• Z is OH, OR, CH2OR, SR, or NR2, where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl;
• and
• each of R10a and R10b is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C6-C20 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted;
• or
• R10a and R10b may be taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl or a C3-C8 heterocyclyl ring, which may be optionally substituted, provided the compound is not:
• wherein:
• (a) R1 and R2 are taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member;
• (b) at least one of R8 and R9 is COOR11 or CONR112;
• (c) Z is OH;
• (d) R10a and R10b are the same;
• (e) R10a and R10b are taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl or a C3-C8 heterocyclyl ring, which may be optionally substituted, and which may be optionally fused to a substituted or unsubstituted phenyl ring to provide an indenyl or tetrahydronaphthyl ring system;
• or
• (f) each of m and m″ is 0 or 1;
• Y is halo when m is 1;
• and Y″ is halo, OH, or C1-C4 alkoxy when m″ is 1.