Amide derivative
AssigneeDaiichi Sankyo Company, Limited
InventorsTakuya Ikeda, Takanori Yamazaki, Hiroshi Tsuchida
Life of this patent
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Abstract
Compounds or pharmacologically acceptable salts thereof are provided. In various embodiments the compounds have an antagonistic effect on a neurokinin NK1 receptor, a neurokinin NK2 receptor, and a muscarine M3 receptor. The compounds are useful as therapeutic agents for bronchial asthma, chronic obstructive pulmonary disease, or the like.
Claims29
A compound of formula (I) or a pharmacologically acceptable salt thereof:
- wherein
- R1 represents a hydrogen atom, a C1-C6 alkyl group, a (C3-C6 cycloalkyl)methyl group, a C2-C7 alkoxycarbonyl group or a benzyl group,
- R2 represents a hydrogen atom, a C1-C6 alkyl group or a C2-C7 alkoxycarbonyl group,
- R3 represents a phenyl group optionally substituted with 1 to 5 groups each independently selected from Substituent Group A or a heterocyclic group optionally substituted with 1 to 3 groups each independently selected from Substituent Group A,
- R4 represents a phenyl group optionally substituted with 1 to 5 groups each independently selected from Substituent Group A or a heterocyclic group optionally substituted with 1 to 3 groups each independently selected from Substituent Group A,
- L1 represents a C1-C10 alkylene group or a C1-C10 alkylene group in which one methylene group is replaced by an oxygen atom and when R1 is a C1-C6 alkyl group, any carbon atom of R1 optionally binds to any carbon atom of L1,
- L2 represents a carbonyl group, a hydroxymethylene group, an ester group, a group represented by a formula —N(R5)—, a group represented by a formula —N(R5)—C(═O)—, a group represented by a formula —C(═O)—N(R5)—, a group represented by a formula —N(R5)—C(═O)—O— or a group represented by a formula —O—C(═O)—N(R5) wherein R5 represents a hydrogen atom, a C1-C6 alkyl group, a C3-C6 cycloalkyl group or a C1-C6 alkoxy group,
- E represents a phenylene group optionally substituted with 1 to 4 groups each independently selected from Substituent Group A, or a heteroarylene group optionally substituted with 1 or 2 groups each independently selected from Substituent Group A, wherein E binds to a methylene group on either side via a carbon atom thereof and when R1 or R5 is a C1-C6 alkyl group, any carbon atom of R1 or R5 optionally binds to any carbon atom of E,
- m represents an integer of 1 to 4,
- n represents an integer of 0 to 4,
- p represents an integer of 0 to 2,
- q represents an integer of 1 to 10,
- r represents 1 or 2,
- s represents 0 or 1, and
- Substituent Group A represents a group consisting of a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a hydroxy group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, a cyano group, a carboxyl group, a C2-C7 alkylcarbonyloxy group, a C2-C7 alkoxycarbonyloxy group, a carbamoyl group, a nitro group, and an amino group.
A compound or a pharmacologically acceptable salt thereof, selected from 1-{2-[{6-[({5-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}methyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-(6-[{3-[([(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]pyridin-3-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({5-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]pyrimidin-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({4-[{2-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino)ethyl}(methyl)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{[3-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)propoxy]acetyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{3-[2-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)ethoxy]propanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-[5-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)pentanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{4-[{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}(methyl)amino]butanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{5-[{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}(methyl)amino]pentanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{6-[{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]benzyl}(methyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]benzyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{6-[{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}(methyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({4-[{4-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butanoyl}(methyl)amino]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({6-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-1,3-benzothiazol-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[(N-{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}-β-alanyl)(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({5-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-4-methyl-1,3-thiazol-2-yl}amino)hexanoyl] (methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate and 1-{2-[{6-[(4-{[4-({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)-1,4-diazepan-1-yl]carbonyl}phenyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate.
1-{2-[{6-[({5-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}methyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({6-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]pyridin-3-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({5-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]pyrimidin-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({4-[{2-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino)ethyl}(methyl)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{[3-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)propoxy]acetyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{3-[2-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl)-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl)ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)ethoxy]propanoyl}(methyl)amino}ethyl]piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[5-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)pentanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{4-[{4-[{3-[([(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl)-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}(methyl)amino]butanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{4-[{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}(methyl)amino]pentanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({4-[{3-[({[(2S)-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{6-[{4-[{3-[({[(2S)-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]benzyl}(methyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]benzyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[{6-[{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}(methyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({4-[{4-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butanoyl}(methyl)amino]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-({6-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-1,3-benzothiazol-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate, 1-{2-[(N-{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}-β-alanyl)(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate, 1-(2-{[6-(5-[{3-[([(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-4-methyl-1,3-thiazol-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate or 1-{2-[{6-[(4-{[4-({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl)ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)-1,4-diazepan-1-yl]carbonyl}phenyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate.
1-(2-{[6-({4-[{2-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]ethyl}(methyl)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate.
1-(2-{[5-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4]-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)pentanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate trihydrochloride.
1-{2-[{4-[{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}(methyl)amino]butanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate trihydrochloride.
1-{2-[{5-{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl)ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}(methyl)amino]pentanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate trihydrochloride.
1-(2-{[6-({4-[{3-[([{[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate.
1-{2-[{6-[{4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]phenyl}(methyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate.
1-(2-{[6-({5-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-4-methyl-1,3-thiazol-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate trihydrochloride.
1-{2-[{6-[(4-{[4-({[(2S)-1′-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)-1,4-diazepan-1-yl]carbonyl}phenyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate trihydrochloride.
Dependencies are inferred from the claim text.