Intravenous formulation with water-soluble cocrystals of acetylsalicylic acid and theanine
AssigneeTheaprin Pharmaceuticals Inc.
InventorsHarry Brittain, Philip V. Felice
Life of this patent
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Abstract
A method of treatment using a water-soluble cocrystal composition contains a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer selected from an alpha variant of theanine or a beta variant of theanine or other form of theanine.
Claims24
A method of treating pain by administering an effective amount of a water-soluble composition comprising:
- a cocrystal composition containing a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer selected from the group consisting of L-theanine, D-theanine, and DL-theanine.
A method of treating pain by administering an effective amount of a water-soluble composition comprising a cocrystal composition containing a quantity of acetylsalicylic acid and a quantity of L-Theanine, the composition made by a process comprising the steps of:
- providing a quantity of acetylsalicylic acid;
- adding a quantity of L-Theanine to said quantity of acetylsalicylic acid to form a mixture comprising said quantity of acetylsalicylic acid and said L-Theanine;
- wetting said mixture;
- and grinding said mixture for a length of time sufficient to produce a dried crystalline mass.
A method of treating pain by administering an effective amount of a water-soluble composition comprising a cocrystal composition containing a quantity of acetylsalicylic acid and a quantity of L-Theanine, the composition made by a process comprising the steps of:
- providing a quantity of acetylsalicylic acid;
- adding a quantity of L-Theanine to said quantity of acetylsalicylic acid to form a mixture comprising said quantity of acetylsalicylic acid and said quantity of L-Theanine;
- dissolving said mixture in a quantity of a first solvent to form a solution;
- and
- drying said solution for a length of time sufficient to produce a dried crystalline mass of an acetylsalicylic acid-theanine cocrystal composition.
A method of treating pain by administering an effective amount of a water-soluble acetylsalicylic acid-theanine cocrystal composition, the composition made by a method comprising the steps of:
- providing a quantity of acetylsalicylic acid;
- adding a quantity of a theanine enantiomer selected from the group consisting of L-theanine, D-theanine, and DL-theanine to said quantity of acetylsalicylic acid to form a mixture comprising said quantity of acetylsalicylic acid and said enantiomer of theanine;
- wetting said mixture;
- and
- grinding said mixture for a length of time sufficient to produce a dried crystalline mass.
A method of treating pain by administering an effective amount of a water-soluble acetylsalicylic acid-theanine cocrystal composition, the composition made by a method comprising the steps of:
- providing a quantity of acetylsalicylic acid;
- adding a quantity of a theanine enantiomer selected from the group consisting of L-theanine, D-theanine, and DL-theanine to said quantity of acetylsalicylic acid to form a mixture comprising said quantity of acetylsalicylic acid and said quantity of a theanine enantiomer;
- dissolving said mixture in a quantity of a first solvent to form a solution;
- and
- drying said solution for a length of time sufficient to produce a dried crystalline mass of an acetylsalicylic acid-theanine cocrystal composition.
A method of treating a symptom of intractable headaches in a human subject comprising administering to the human subject in need thereof an effective dose of a water-soluble composition, the composition comprising:
- a cocrystal composition containing a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer selected from the group consisting of L-theanine, D-theanine, and DL-theanine, effective to alleviate the symptom of premenstrual syndrome.
Dependencies are inferred from the claim text.