Process for the preparation of a water-soluble complex having resveratrol compounds; products comprising said complex; and uses thereof

A nutraceutical composition comprising as active and/or functional component a trans-resveratrol and β-cyclodextrin compound complex in a solid crystalline form, and a nutraceutically acceptable vehicle,

• wherein said trans-resveratrol and β-cyclodextrin compound complex is produced from a process comprising the steps of:
• a) completely homogenizing β-cyclodextrin in water with heating from 50 to 80° C., up to a β-cyclodextrin concentration lower than or equal to 60 mM;
• b) adding, to the solution resulting from step (a), a water miscible and physiologically acceptable organic solvent, up to an organic solvent:water ratio ranging from 1:1 to 1:5;
• c) adding, to the mixture resulting from step (b), a solution of a trans-resveratrol compound diluted in a water miscible and physiologically acceptable organic solvent, and heating the resulting mixture at a temperature range from 50 to 80° C.;
• d) cooling slowly the solution resulting from step (c) until precipitation from the mixture of crystals of the resveratrol and cyclodextrin compound complex;
• and
• e) separating out the crystals of the resveratrol and cyclodextrin compound complex,
• wherein the resveratrol and cyclodextrin compound complex is in a solid crystalline form and has a solubility of about 3010 mg/L in water.

A pharmaceutical composition comprising as active and/or functional component a trans-resveratrol and β-cyclodextrin compound complex in a solid crystalline form, and a pharmaceutically acceptable vehicle,

• wherein said trans-resveratrol and β-cyclodextrin compound complex is produced from a process comprising the steps of:
• a) completely homogenizing β-cyclodextrin in water with heating from 50 to 80° C., up to a β-cyclodextrin concentration lower than or equal to 60 mM;
• b) adding, to the solution resulting from step (a), a water miscible and physiologically acceptable organic solvent, up to an organic solvent:water ratio ranging from 1:1 to 1:5;
• c) adding, to the mixture resulting from step (b), a solution of a trans-resveratrol compound diluted in a water miscible and physiologically acceptable organic solvent, and heating the resulting mixture at a temperature range from 50 to 80° C.;
• d) cooling slowly the solution resulting from step (c) until precipitation from the mixture of crystals of the resveratrol and cyclodextrin compound complex;
• and
• e) separating out the crystals of the resveratrol and cyclodextrin compound complex,
• wherein the resveratrol and cyclodextrin compound complex is in a solid crystalline form and has a solubility of about 3010mg/L in water.