Inhibition of tumor growth and invasion by anti matrix metalloproteinase DNAzymes
AssigneeUniversity of Tennessee Research Foundation
InventorsTayebeh Pourmotabbed, Hisashi Hasegawa, Chad Batson
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Abstract
The presently disclosed subject matter provides DNA molecules designed to down regulate the expression of MMP genes in a cell. Also provided are compositions comprising the DNA molecules. The presently disclosed subject matter further provides methods of using the DNA molecules to inhibit metastasis of a cancer cell. The presently disclosed subject matter also provides methods of using the DNA molecules to modulate tumor growth in a subject.
Claims6
A method of modulating cellular expression of at least one matrix metalloproteinase protein, the method comprising introducing into a cell at least one DNA oligonucleotide having binding specificity for a target region of a messenger ribonucleotide (mRNA) encoding a matrix metalloproteinase protein, wherein the at least one matrix metalloproteinase protein is MMP-2, MMP-9, or both MMP-2 and MMP-9, and wherein the DNA oliqonucleotide has a nucleotide sequence comprising the sequence of SEQ ID NO:
- 1, SEQ ID NO:
- 3 or SEQ ID NO:
- 22.
Dependencies are inferred from the claim text.