Methods and compositions for treating keratin hyperproliferative disorders

A method of treating a hyperproliferation skin disorder in a subject who is manifesting a hyperproliferation disorder, comprising:

• administering to the subject who is manifesting a hyperproliferation disorder selected from the group consisting of keratosis pilaris, calluses, corns, psoriasis, keratosis follicularis, pityriasis rubra pilaris, and Clouston syndrome, a therapeutically effective amount of an RNA sequence which inhibits expression of a gene encoding for a keratin selected from the group consisting of K6a, K6b, K16, K17, and combinations thereof, wherein the inhibited gene encodes the K6a keratin and the RNA sequence is a member selected from the group consisting of:
• SEQ. ID NO:
• 2, SEQ. ID NO:
• 4, SEQ. ID NO:
• 6, SEQ. ID NO:
• 8, SEQ. ID NO:
• 10, SEQ. ID NO:
• 12, SEQ. ID NO:
• 14, SEQ. ID NO:
• 16, SEQ. ID NO:
• 18, SEQ. ID NO:
• 20, SEQ. ID NO:
• 86, SEQ. ID NO:
• 91, SEQ. ID NO:
• 92, SEQ. ID NO:
• 94, and combinations thereof.