Treatment of skin conditions by Dickkopf1 (DKK1)
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsVincent Hearing, Yuji Yamaguchi, Thierry Passeron
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Abstract
The present disclosure is generally related to methods of inducing non-palmoplantar skin to develop a palmoplantar phenotype, for example, methods for increasing skin thickness, decreasing skin pigmentation, and/or decreasing hair growth. In particular, disclosed herein are methods of using topical administration of DKK1 to increase skin thickness, decrease skin pigmentation, or reduce hair growth. Also disclosed are topical DKK1 compositions for inducing non-palmoplantar skin to develop a palmoplantar phenotype.
Claims24
A method for treating a wound, comprising:
- applying a skin graft derived from non-palmoplantar skin or from tissue engineered from fibroblasts to a wound;
- and
- topically applying an effective amount of DKK1 to the skin graft before or after applying the skin graft to the wound, thereby inducing the non-palmoplantar skin or tissue engineered from fibroblasts to develop a palmoplantar phenotype and treating the wound.
A method for increasing skin thickness in a subject, comprising:
- topically applying an effective amount of DKK1 to thin non-palmoplantar skin, thereby inducing the thin non-palmoplantar skin to develop a palmoplantar phenotype and increase the skin thickness.
Dependencies are inferred from the claim text.