Insulinotropic complex using an immunoglobulin fragment

An insulinotropic peptide conjugate, comprising an insulinotropic peptide, a non-peptidyl polymer, and an immunoglobulin Fc fragment,

• wherein the insulinotropic peptide and the immunoglobulin Fc fragment are covalently linked through the non-peptidyl polymer;
• wherein the insulinotropic peptide is selected from the group consisting of beta-hydroxy-imidazo-propionyl exendin-4 where the N-terminal amine group of exendin-4 is substituted with hydroxyl group, dimethyl-histidyl exendin-4 where the N-terminal amine group of exendin-4 is modified with two methyl groups, and imidazo-acetyl exendin-4 where the alpha carbon of the first histidine and the N-terminal amine group linked thereto are deleted;
• wherein the non-peptidyl polymer is selected from the group consisting of polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, polyoxyethylated polyols, polyvinyl alcohol, polysaccharides, dextran, polyvinyl ethyl ether, biodegradable polymers, lipid polymers, chitins, hyaluronic acid, and combinations thereof;
• and
• wherein one end of the non-peptidyl polymer is linked to an amino acid residue other than the N-terminus of the insulinotropic peptide.