Insulin derivatives
AssigneeNovo Nordisk A/S
InventorsJános Tibor Kodra, Patrick William Garibay, Thomas Hoeg-Jensen, Ib Jonassen, Peter Madsen, Tina Møller Tagmose
Life of this patent
Estimating the term…
Abstract
The present invention relates to insulin derivatives having a side chain attached either to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys residue present in the B chain of the parent insulin via an amide bond which side chain comprises at least one aromatic group; at least one free carboxylic acid group or a group which is negatively charged at neutral pH, a fatty acid moiety with 4 to 22 carbon atoms in the carbon chain; and possible linkers which link the individual components in the side chain together via amide bonds.
Claims9
An insulin derivative having the formula
- wherein Ins is the parent insulin moiety which via the α-amino group of the N-terminal amino acid residue of the B chain or an ε-amino group of a Lys residue present in the B chain of the insulin moiety is bound to the CO— group in the side chain via an amide bond;
- X1 is a bond;
- W is an arylene;
- m is 1;
- X is a bond;
- Y is —(CR1R2)q—NR—CO—, where R1 is H, R2 is H, q is 1;
- and R —(CH2)p—COOH where p is 2;
- Q is —(CH2)r— where r is 14;
- and
- Z is —COOH;
- and any Zn2+ complex thereof.
Dependencies are inferred from the claim text.