Antiviral compounds

A compound of formula 1:

• or a pharmaceutically acceptable salt thereof;
• wherein:
• R1 is R2—, R2—C(O)—, R2—O—C(O)— or R2—N(H)—C(O)—
• R2 is optionally substituted C1-C8 alkyl, optionally substituted C3-C10 cycloalkyl, optionally substituted C7-C14 cycloalkylalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heterocycle or optionally substituted heterocyclylalkyl;
• R3 is optionally substituted C1-C8 alkyl, optionally substituted C3-C10 cycloalkyl, optionally substituted C7-C14 cycloalkylalkyl, optionally substituted heterocyclylalkyl, or optionally substituted heterocycle, or R3 and R8, along with the atoms that connect them, form a 12 to 18 membered saturated, partially unsaturated or unsaturated heterocycle wherein the 12 to 18 membered saturated, partially unsaturated or unsaturated heterocycle is optionally substituted with C1-C6 alkyl, C1-C6-haloalkyl, halo, oxo or cyano and wherein 0, 1, 2, or 3 carbon atoms of R3 are optionally replaced by O, N, or S;
• R4 is R6—, R6—R5—, R6—W—, R6—W—C(O)—, R6—C(O)—, R6—C(O)—W—, R6—W—O—C(O)—, R6—S(O)m—, R6—W—S(O)m—, R6—N(H)—C(O)—, R6—N(H)—S(O)m—, R6—R5—S(O)m—, or R6—N(H)—R5—;
• R5 is optionally substituted arylene or optionally substituted heteroarylene;
• R6 is optionally substituted C3-C10 cycloalkyl, optionally substituted aryl or optionally substituted heterocycle;
• m is 0, 1 or 2:
• W is C1-C4 alkylene, C2-C4 alkenylene, or C2-C4alkynylene wherein the C1-C4 alkylene, C2-C4 alkenylene, or C2-C4 alkynylene is optionally substituted with C1-C3-alkyl, C1-C3-haloalkyl, cyano or halo;
• R7 is:
• R8 is C1-C4 alkyl, C2-C4 alkenyl or C2-C4-alkynyl wherein the C1-C4 alkyl, C2-C4 alkenyl or C2-C4-alkynyl is optionally substituted with halo or cyano;
• R9 is R10, R10—NH— or R10—O—
• R10 is C1-C4 alkyl, C3-C7 cycloalkyl or C4-C9 cycloalkylalkyl wherein the C1-C4 alkyl, C3-C7 cycloalkyl or C4-C9 cycloalkylalkyl is optionally substituted with C1-C2-alkyl, C1-C2-haloalkyl, cyano or halo;
• R11 is C1-C4 alkyl, C3-C7 cycloalkyl or C4-C9 cycloalkylalkyl wherein the C1-C4 alkyl, C3-C7 cycloalkyl or C4-C9 cycloalkylalkyl is optionally substituted with C1-C2-alkyl, C1-C2-haloalkyl, C1-C4-alkylthio, cyano or halo;
• each R12 is independently H, C1-C6 alkyl, C3-C7 cycloalkyl or C4-C9 cycloalkylalkyl wherein the C1-C6 alkyl, C3-C7 cycloalkyl or C4-C9 cycloalkylalkyl is optionally substituted with C1-C2-alkyl, C1-C2-haloalkyl, cyano or halo;
• R13 is H, OH, OR14, C1-C4 alkyl, C3-C7 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, arylalkyl, heterocycle or heterocyclylalkyl wherein the C1-C4 alkyl, C3-C7 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, arylalkyl, heterocycle or heterocyclylalkyl is optionally substituted with C1-C2-alkyl, C1-C2-haloalkyl cyano or halo;
• R14 is R15—, R15—C(O)—, R15—O—C(O)—, or R15O—C(O)—X—
• R15 is C1-C6 alkyl, C3-C7 cycloalkyl, C7-C12 cycloalkylalkyl, aryl, arylalkyl, heterocycle, or heterocyclylalkyl wherein the C1-C6 alkyl, C3-C7 cycloalkyl, or C7-C12 cycloalkylalkyl is optionally substituted with C1-C2-alkyl, C1-C2-haloalkyl, cyano or halo;
• X is C1-C5 alkylene or C3-C6 spiroalkylene;
• R16 is H, R17—C(O)—, R17—O—C(O)— or R17O—C(O)—X—;
• each R17 is independently H, C1-C4 alkyl, C3-C7 cycloalkyl or C4-C9 cycloalkylalkyl wherein the C1-C4 alkyl, C3-C7 cycloalkyl or C4-C9 cycloalkylalkyl is optionally substituted with C1-C2-alkyl, C1-C2-haloalkyl, cyano or halo, or two R17, along with the carbon to which they are attached, form a 3-6 membered spirocyclic carbocycle or heterocycle wherein any carbon of said carbocycle or heterocycle is optionally substituted with C1-C2-alkyl, C1-C2-haloalkyl, cyano or halo and any nitrogen of said heterocycle is optionally substituted with C1-C2-alkyl, C1-C2-haloalkyl, C3-C5 cycloalkyl or C1-C3 acyl, or, taken together, two instances of R17 together with the carbon atom to which they are attached form a carbonyl group.