Method for differentiating between the non-infectious and infectious causes of multiple organ failure

A method of differentiating between the non-infectious and infectious causes of multiple organ failure in a human subject, comprising:

• a. isolating sample RNA from a blood sample from said human subject;
• b. selecting at least two genes and/or gene fragments specific for differentiating non-infectious and infectious causes of multiple organ failure from a group consisting of:
• SEQ ID NO. 1 to SEQ ID NO. 1297 as well as gene fragments thereof with at least 20-2000 nucleotides;
• c. quantitatively measuring the level of expression of said at least two genes and/or gene fragment;
• d. comparing the quantitative data of the expression level of said at least two genes and/or gene fragments against an expression level of said at least two genes and/or gene fragments of a patient with non-infectious multiple organ failure;
• and
• e. in the case that said genes and/or gene fragments selected from the group consisting of SEQ ID NO:1-721 are expressed more in the sample than in the patient with non-infectious multiple organ failure, diagnosing the human subject as having risk of infectious multiple organ failure and in the case that said at least two genes and/or gene fragments selected from the group consisting of SEQ ID NO:
• 722-1297 are decreased more in the sample than in the patient with non-infectious multiple organ failure, diagnosing the human subject as having risk of infectious multiple organ failure.