Bacillus strain for increased protein production
AssigneeDanisco US Inc.
InventorsCristina Bongiorni, Eugenio Ferrari
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Abstract
The present invention provides host cells that have been genetically manipulated to have an enhanced capacity to produce proteins of interest. In particular, the invention relates to modified Bacillus sp. Host cells that have at least one inactivated phr gene. The enhanced production of proteins of interest by the modified Bacillus sp. Host cells is further increased in modified Bacillus sp. Host cells that overexpress YmaH. Methods for producing proteins of interest in the modified host cells are also provided.
Claims30
A host cell comprising a rap operon comprising at least one inactivated rap gene, wherein said host cell further overexpresses YmaH.
A method for producing at least one protein of interest comprising providing a host cell comprising a rap operon comprising at least one inactivated rap gene, wherein said host cell further overexpresses YmaH;
- and growing said host cell under suitable conditions for producing said at least one protein of interest.
Dependencies are inferred from the claim text.