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US 8,476,037 B2Granted
Method for screening of antiviral agents
AssigneesUniversity of Medicine and Dentistry of New Jersey, The Trustees of the University of Pennsylvania
InventorsMasayori Inouye, Lili Mao, William F. Degrado, Nathan H. Joh
Life of this patent
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Abstract
A method for screening for an antiviral agent capable of blocking a viral viroporin by determining whether a test agent can rescue expression of a fragment of a viral viroporin in a Single Protein Production system of Escherichia coli is provided.
Claims2
A method for screening for an antiviral agent capable of blocking a viral viroporin comprising
- inducing expression of a viral viroporin fragment in a Single Protein Production system of Escherichia coli (E. coli);
- contacting the E. coli with a test compound;
- and
- determining whether expression of the viral viroporin fragment is rescued,
- wherein rescue of the expression of the viral viroporin fragment indicates that the test compound blocks the viral viroporin.
2 more elements
Dependencies are inferred from the claim text.