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US 8,476,028 B2Granted
Sepsis test
AssigneeKing's College London
InventorsKenneth Alun Brown, Sion Marc Lewis
Life of this patent
Estimating the term…
Abstract
There is provided a method for determining whether a subject has a bacterial infection comprising: identifying an abnormal expression of one or more of CD49e, CD 14, CD11c, CD49f, and CD29 on leucocytes in a sample obtained from the subject; wherein an abnormal expression of CD49e, CD 14, CD11c, CD49f or CD29 is indicative of the subject having a bacterial infection.
Claims7
A method for determining whether a subject has a bacterial infection comprising:
- contacting detectably labeled antibodies specific for CD49e, TLR2, and TLR4 with blood leucocytes in a sample obtained from the subject;
- forming a measurable amount of CD49e-antibody complex, TLR2-antibody complex, and TLR4-antibody complex;
- identifying abnormal expression of CD49e on blood leucocytes in a sample obtained from the subject from the amount of CD49e-antibody complex;
- and
- identifying abnormal expression of one or both of TLR2 and TLR4 on the blood leucocytes in the sample from the amount of TLR2-antibody complex and TLR4-antibody complex, wherein abnormal expression of CD49e and of one or both of TLR2 and TLR4 is indicative of the subject having a bacterial infection.
2 more elements
Dependencies are inferred from the claim text.