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US 8,476,026 B2Granted
Biomarkers of ovarian cancer
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsNg Alex, Brian Liu
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Abstract
The invention is directed to assays for biomarkers associated with ovarian cancer that can be used diagnostically. It includes glass or plastic plates or slides on which the biomarkers have been immobilized and kits containing these plates or slides.
Claims19
A method of diagnostically evaluating a female subject for ovarian cancer, comprising:
- a) obtaining a test biological sample of blood, plasma, or serum from said female subject;
- b) assaying said test biological sample for casein kinase 1, epsilon using an antibody profiling assay;
- c) comparing the results obtained in step b) with the results of an assay of casein kinase 1, epsilon in a control sample;
- wherein an elevated level of autoantibodies specific for casein kinase 1, epsilon in said test biological sample relative to said control sample, is an indication that said subject has ovarian cancer.
1 more element
Dependencies are inferred from the claim text.