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US 8,476,025 B2Granted
ATM-dependent phosphorylation of Sp1 is involved in the cellular response to DNA damage and enhances cellular survival after DNA damage
AssigneePhiladelphia Health and Education Corporation
InventorsJane Clifford, Beatrix A. Olofsson, Crystal M. Kelly
Life of this patent
Estimating the term…
Abstract
The present invention is related to the discovery that phosphorylation of SP1 (SEQ ID NO.: 2) at serine residue 101 (known herein as phosphoserine101 Sp1) is an important part of a cell's response to DNA damage. This phosphorylation event is important for subsequent Sp1 localization to a site of DNA damage and is correlated with increased cellular viability in response to DNA damage.
Claims5
An antibody that specifically binds to the polypeptide of SEQ ID NO:
- 2 having a phosphate moiety at serine residue 101 relative to SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.