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US 8,475,845 B2Granted
Method of particle formation
AssigneeMAP Pharmaceuticals, Inc.
InventorsLinda Sze Tu, Hubert Leonardus Regtop, Neil Russell Foster, Pascal Hickey
Life of this patent
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AssigneeMAP Pharmaceuticals, Inc.
InventorsLinda Sze Tu, Hubert Leonardus Regtop, Neil Russell Foster, Pascal Hickey
Estimating the term…
A method of co-formulating two or more pharmaceutically active compounds into a particulate product including contacting a dense, supercritical or near-critical fluid With a suspension of a first active compound in a medium that is miscible with the dense fluid and a solution of a second active compound in a solvent that is miscible with the dense fluid. The product may be the first active agent coated with the second active agent. The method may use coaxial nozzles for the fluid, media or solvents. The method may be applied to production of dry powders for inhalation including beta-agonists and corticosteroids. Apparatus for use in the method comprising means for streams of solvents, media and dense fluids to enter a precipitation chamber at substantially the same point and means for collection of particles under gravity in one or more collection chambers.
A method of coformulating two or more pharmaceutically active compounds to form a particulate product, the method comprising:
An apparatus for forming a particulate product containing two or more components including a precipitation chamber, the precipitation chamber being connected to three or more conduits, each conduit having an exit in to the precipitation chamber and being adapted to carry a stream of a dense fluid, solution or suspension, and wherein the three or more conduits are arranged such that after each stream exits its conduit, the three or more streams intersect at substantially the same point, the apparatus also having means to convey the fine particles from the precipitation chamber to at least one particle collection chamber, downstream of the precipitation chamber, the particle collection chamber having an inlet and an outlet separate from the inlet in which the outlet is disposed above the inlet in use of the apparatus, such that gravity exerts a force generally towards the inlet on particles adjacent the outlet.
A method of coformulating two or more pharmaceutically active compounds into a particulate product, the method comprising contacting a dense fluid with:
Dependencies are inferred from the claim text.