Sustained release formulation for oral administration of HMG-CoA reductase inhibitor and method for the preparation thereof
AssigneeHanmi Science Co., Ltd.
InventorsJong Soo Woo, Hong-Gi Yi, Moon-Hyuk Chi, Jae-Kuk Ryu, Si-Young Jung, Yong-Il Kim
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Abstract
The sustained release formulation for oral administration of an HMG-CoA reductase inhibitor of the present invention can be easily and economically prepared and is capable of maintaining a constant drug level in blood by slowly releasing the HMG-CoA reductase inhibitor at a uniform rate for 24 hrs. Accordingly, the sustained release formulation of the present invention can be effectively used for lowering blood cholesterol and triglyceride levels.
Claims15
A sustained release formulation for oral administration of an HMG-CoA reductase inhibitor comprising:
- a spray-dried solid dispersant in the form of particles having a particle size ranging from 5 to 200 μm, wherein the solid dispersant contains the HMG-CoA reductase inhibitor, a solubilizing agent, and a stabilizing agent;
- a mixture of sodium alginate and xanthan gum as a sustained release composite carrier;
- and
- a mixture of propylene glycol ester alginate and hydroxypropyl methyl cellulose as a gel hydration accelerator.
A sustained release formulation for oral administration of an HMG-CoA reductase inhibitor comprising:
- a spray-dried solid dispersant in the form of particles having a particle size ranging from 5 to 200 μm, wherein the solid dispersant consists of the HMG-CoA reductase inhibitor, a solubilizing agent, and a stabilizing agent;
- a mixture of sodium alginate and xanthan gum as a sustained release composite carrier;
- and
- a mixture of propylene glycol ester alginate and hydroxypropyl methyl cellulose as a gel hydration accelerator.
Dependencies are inferred from the claim text.