Rapidly-dissolving pharmaceutical composition for inhibiting ovulation
AssigneeSandoz Ltd.
InventorsPablo Davila, Paola Henar Paniagua Marcos, Benito Lorenzo Pajuelo
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Abstract
A rapidly-dissolving oral dosage pharmaceutical composition for inhibiting ovulation in a mammal, said composition comprising drospirenone or a pharmaceutically acceptable salt or ester thereof, optionally ethinyl estradiol or a pharmaceutically acceptable salt, ester or ether thereof, a surfactant and at least one pharmaceutically acceptable excipient, wherein the drospirenone has a surface area of less than 10,000 cm2/g.
Claims10
A rapidly-dissolving oral dosage pharmaceutical composition for inhibiting ovulation in a mammal, said composition comprising drospirenone or a pharmaceutically acceptable salt or ester thereof, a polyoxyethylene-sorbitan-fatty acid ester surfactant and at least one pharmaceutically acceptable excipient, wherein the drospirenone is in the form of solid particles having a surface area of less than 10,000 cm2/g and greater than 2% of said particles have a diameter of at least 30 μm, and wherein the surfactant is present in an amount of from about 0.01 wt % to about 20 wt %, based on the total weight of the composition.
Dependencies are inferred from the claim text.