Tissue implants for implantation and methods for preparing the same
AssigneeCryolife, Inc.
InventorsJoseph Hamby, Steven Walsh, Al Heacox, Steven Goldstein, David Gale, Stacy Arnold, Ann Sands Updegrove
Life of this patent
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Abstract
A method is provided for preparing a tissue implant for implantation. The method includes treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution; and thereafter treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof.
Claims21
A method of preparing a tissue implant for implantation comprising:
- treating an essentially acellular tissue material with a chlorine dioxide treatment solution;
- and thereafter
- treating the tissue material with an antioxidant-containing solution in an amount effective to degrade the chlorine dioxide, remaining in the tissue material following treatment with the chlorine dioxide treatment solution.
A method of preparing a tissue implant for implantation comprising:
- treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution;
- and thereafter
- treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof, to degrade the chlorine dioxide, remaining in the pericardium tissue material following treatment with the chlorine dioxide treatment solution.
A method of preparing a tissue implant for implantation comprising:
- treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution;
- and thereafter
- treating the pericardium tissue material with an antioxidant solution;
- vacuum sealing the pericardium tissue material in a package with the antioxidant solution to form a packaged tissue material;
- and
- sterilizing the packaged tissue material with ionizing radiation,
- wherein the antioxidant solution is effective to degrade the chlorine dioxide, remaining in the pericardium tissue material following treatment with the chlorine dioxide treatment solution and/or to act as a radioprotectant during the sterilization.
Dependencies are inferred from the claim text.