Resorbable matrix having elongated particles
AssigneeWarsaw Orthopedic, Inc.
InventorWilliam F. McKay
Life of this patent
Estimating the term…
Abstract
Compression resistant matrices and methods are provided that have elongated particles embedded therein. The compression resistant matrices provide improved stability and mechanical strength and resists shifting, extrusion and rotation after implantation. In some embodiments, the matrices provided reduce or prevent surface compression of the implantable matrix which will cause unwanted increased amounts of growth factor (e.g., bone morphogenic protein) to leak from the matrix.
Claims16
An implantable matrix configured to fit at or near a target tissue site, the matrix comprising:
- a biodegradable polymer and a plurality of elongated particles embedded within the polymer, the elongated particles embedded in the polymer uniformly or randomly so as to reduce compression of the matrix, wherein the matrix includes a plurality of pores between about 50 μm and 500 μm and has a porosity of at least 30% such that the matrix allows influx of at least progenitor, bone and/or cartilage cells therein, wherein the elongated particles comprise tricalcium phosphate and hydroxyapatite in a ratio of about 80:20 to about 90:10, and the elongated particles represent at least 50 to 98 weight percent of the matrix.
An implantable matrix configured to fit at or near a target tissue site, the matrix comprising:
- collagen and a plurality of elongated mineral particles embedded within the collagen, the elongated mineral particles embedded in the collagen uniformly or randomly so as to reduce compression of the matrix, wherein the matrix includes a plurality of pores between about 50 μm and 500 μm and has a porosity of at least 30% such that the matrix allows influx of at least progenitor, bone and/or cartilage cells therein;
- and the matrix comprises bone morphogenic protein, herein the elongated particles comprise tricalcium phosphate and hydroxyapatite in a ratio of about 80:20 to about 90:10, and the elongated particles represent at least 50 to 98 weight percent of the matrix.
Dependencies are inferred from the claim text.