US 8,475,822 B2Granted

Room temperature-curable polymers

AssigneeAbbott Laboratories

InventorDale E. Hauenstein

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Abstract

Methods of making room temperature-curable polymers. Reactants include siloxane-terminated polymers and silanols. The reactants are mixed, and the polymerization allowed to proceed in air at room temperature. The polymers are exceptionally useful because they allow for the incorporation into the polymers themselves of one or more therapeutic compounds. Thus, medical devices from which controlled drug release is desirable (for either local or systemic delivery) can be coated with therapeutic compound-containing polymers of the invention. In a preferred embodiment, a polymer of poly(MPCw:LAMx:HPMAy:TSMAz) where w, x, y, and z represent the molar ratios of monomers used in the feed for preparing the polymer; MPC represents the unit 2-methacryoyloxyethylphosphorylcholine, LMA represents the unit lauryl methacrylate, HPMA represents the unit 2-hydroxypropyl methacrylate, and TSMA represents the unit 3-trimethoxysilylpropyl methacrylate is reacted with polydimethylsiloxane. In another preferred embodiment, a therapeutic compound is incorporated into the polymer, such as dexamethasone.

Claims12

Dependent claims

A method of coating a medical device, comprising preparing a composition which comprises at least one therapeutic compound and a molecule of formula IV:

wherein the preparing step comprises
reacting a molecule of formula I:
with a molecule of formula II:
adding the therapeutic compound to reactant of formula I or reactant of formula II or both prior to the reaction thereof, or adding the therapeutic compound to the reaction mixture of the reactants during the reaction thereof;
wherein R1 comprises a polymer, the polymer is in part polycarboxylic acid, cellulosic polymer, gelatin, polyvinylpyrrolidone, maleic anhydride polymer, polyamide, polyvinyl alcohol, polyethylene oxide, glycosaminoglycan, polysaccharide, polyester, silicone, polyurethane, polyorthoester, polyanhydride, polycarbonate, polypropylenes, polylactic acid, polyglycolic acid, polycaprolactone, polyhydroxybutyrate valerate, polyacrylamide, polyether, and a mixture and copolymer thereof;
R2, R3, R4, R5, R6 and R7 are alkyls or silanol-terminated alkyls;
wherein n is an integer, 1≦n≦100;
wherein the reaction is carried out at a temperature compatible with the therapeutic compound;
and
applying the composition to the surface of the medical device.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/019,556Filed 2 Feb 2011 · continuation
Priority: 21 Dec 2005
Published: US 2011/0123702 A126 May 2011
Granted: 2 Jul 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification26 codes

C08G 77/442
Block-or graft-polymers containing polysiloxane sequences: containing vinyl polymer sequences
A61L 29/10
Materials for coatings: inorganic materials
A61L 29/16
Materials characterised by their function or physical properties , e.g. lubricating compositions: biologically active materials, e.g. therapeutic…
A61L 31/10
Materials for coatings: macromolecular materials

Family

Application11/314,372Parent of this continuation · filed 21 Dec 2005
US 2011/0123702 A1Pre-grant publication · published 26 May 2011
US 7,906,134 B2Parent of this continuation
US 2007/0141104 A1Published application
US 8,475,822 B2This patent

From the US filing history. Foreign family members aren’t listed.