Gelatin sponge comprising an active ingredient, its preparation and use
AssigneeOmrix Biopharmaceuticals Ltd.
InventorsIsrael Nur, Eyal Sheetrit, Liliana Bar, Guy Tomer
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Abstract
The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
Claims15
A method for manufacturing an improved cross-linked gelatin sponge comprising a protein or peptide active ingredient comprising the steps of:
- a) providing a cross-linked gelatin sponge having at least one surface;
- b) homogenously applying an aqueous liquid comprising a protein or peptide active ingredient to said at least one surface of said sponge, wherein the volume of the liquid intake into said surface of said sponge is equal to or less than 5% of the volume of the sponge in a);
- and
- c) drying the sponge by a drying step selected from the group consisting of thermal drying, vacuum drying and freeze drying,
- thereby obtaining a flexible, dry cross linked gelatin sponge comprising a stable layer of protein or peptide active ingredient on at least one surface of the sponge.
Dependencies are inferred from the claim text.