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US 8,475,799 B2Granted
HIV-1 GP41 neutralization domain and use thereof
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorAbraham Pinter
Life of this patent
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Abstract
The invention relates to isolated monoclonal antibodies which specifically bind to the C-terminal heptad repeat region of gp41 (HR2) and neutralize an HIV-1 primary isolate.
Claims3
An isolated monoclonal antibody which specifically binds an epitope present on a peptide consisting of the sequence Asn-Tyr-Thr-Xaa1-Xaa2-Ile-Tyr-Xaa3-Leu-Xaa4-Glu-Xaa5-Ser-Gln-Asn-Gln-Gln-Glu-Xaa6-Asn-Glu-Xaa7 (SEQ ID NO:26), wherein Xaa1 is Asp or Asn;
- Xaa2 is Thr or Leu;
- Xaa3 is Lys, Arg, or Thr;
- Xaa4 is Leu or Ile;
- Xaa5 is Lys, Asp, Glu;
- Xaa6 is Glu or Lys;
- and Xaa7 is Lys or Gln.
3 more elements
Dependencies are inferred from the claim text.