Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein
AssigneesInhibitex, Inc., The Texas A&M University System
InventorsJoseph M. Patti, Jeff T. Hutchins, Andrea Hall, Linda Santos, Maria Bowden, Magnus Hook
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Abstract
Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus epidermidis. The monoclonal antibodies of the invention are advantageous in that they can also recognize binding domains and subdomains of the S. epidermidis SdrF protein in addition to the protein itself. Suitable compositions and passive vaccines based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.
Claims17
An isolated monoclonal antibody which binds specifically to the SdrF protein of Staphylococcus epidermidis and which has a variable light chain selected from the group consisting of SEQ ID NO:
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An isolated monoclonal antibody which binds specifically to the SdrF protein of S. epidermidis, wherein said antibody has a variable heavy chain selected from the group consisting of SEQ ID NO:
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Dependencies are inferred from the claim text.