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US 8,475,797 B2Granted
Interferon alpha antibodies and their uses
AssigneeMedarex, Inc.
InventorsAlison Witte, Denise Williams, Josphine M Cardelli, David King, David Passmore
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AssigneeMedarex, Inc.
InventorsAlison Witte, Denise Williams, Josphine M Cardelli, David King, David Passmore
Estimating the term…
The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
A method of treating systemic lupus erythematosus in a subject in need of treatment comprising administering to the subject an effective amount of an isolated anti-interferon alpha monoclonal antibody, or an antigen binding portion thereof, which binds an epitope on a human interferon alpha polypeptide recognized by an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
A method of treating systemic lupus erythematosus in a subject in need of treatment comprising administering to the subject an effective amount of an isolated anti-interferon alpha monoclonal antibody, or antigen binding portion thereof, comprising:
A method of treating systemic lupus erythematosus in a subject in need of treatment comprising administering to the subject an effective amount of an isolated anti-interferon alpha monoclonal antibody, or antigen binding portion thereof, which comprises:
Dependencies are inferred from the claim text.