Anti-folate receptor alpha antibodies and uses thereof
AssigneeEisai R&D Management Co., Ltd.
InventorDaniel John O'Shannessy
Life of this patent
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Abstract
Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, fallopian tube cancer, ovarian cancer, or lung cancer, using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.
Claims8
An isolated antibody, or antigen-binding fragment thereof, specific for folate receptor alpha (FRα) comprising:
- a. a light chain CDR1 having the amino acid sequence of SEQ ID NO:
- 2, a light chain CDR2 having the amino acid sequence of SEQ ID NO:
- 3, a light chain CDR3 having the amino acid sequence of SEQ ID NO:
- 4, a heavy chain CDR1 having the amino acid sequence of SEQ ID NO:
- 6, a heavy chain CDR2 having the amino acid sequence of SEQ ID NO:
- 7, and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO:
- 8;
- b. a light chain CDR1 having the amino acid sequence of SEQ ID NO:
- 10, a light chain CDR2 having the amino acid sequence of SEQ ID NO:
- 11, a light chain CDR3 having the amino acid sequence of SEQ ID NO:
- 12, a heavy chain CDR1 having the amino acid sequence of SEQ ID NO:
- 14, a heavy chain CDR2 having the amino acid sequence of SEQ ID NO:
- 15, and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO:
- 16;
- c. a light chain CDR1 having the amino acid sequence of SEQ ID NO:
- 18, a light chain CDR2 having the amino acid sequence of SEQ ID NO:
- 19, a light chain CDR3 having the amino acid sequence of SEQ ID NO:
- 20, a heavy chain CDR1 having the amino acid sequence of SEQ ID NO:
- 22, a heavy chain CDR2 having the amino acid sequence of SEQ ID NO:
- 23, and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO:
- 24;
- or
- d. a light chain CDR1 having the amino acid sequence of SEQ ID NO:
- 26, a light chain CDR2 having the amino acid sequence of SEQ ID NO:
- 27, a light chain CDR3 having the amino acid sequence of SEQ ID NO:
- 28, a heavy chain CDR1 having the amino acid sequence of SEQ ID NO:
- 30, a heavy chain CDR2 having the amino acid sequence of SEQ ID NO:
- 31, and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO:
- 32.
Dependencies are inferred from the claim text.