Back to results
US 8,475,787 B2Granted
Beneficial effects of bacteriophage treatments
AssigneeBio-Control Limited
InventorDavid Harper
Life of this patent
Estimating the term…
Abstract
The invention relates to use of one or more bacteriophages in vivo in a human or animal in order to induce sensitivity to chemical antibiotics in bacterial cells, where such susceptibility is heritable, independent of continuing bacteriophage metabolism within those cells, and does not relate to the destruction of a biofilm to induce such sensitivity.
Claims16
A method to induce sensitivity to chemical antibiotics in bacterial cells,
- comprising administering one or more bacteriophages in vivo in a human or animal;
- and
- monitoring induction of the sensitivity by antibiotic sensitivity testing in vitro, both before and after the administering of the one or more bacteriophages;
- where the sensitivity is heritable, independent of continuing bacteriophage metabolism within those cells, and does not relate to the destruction of a biofilm to induce sensitivity, and
- the bacterial cells are Pseudomonas aeruginosa.
2 more elements
A method to induce or improve susceptibility to an antibiotic in bacterial cells comprising:
- administering to a human or animal with a bacterial infection, a bacteriophage preparation comprising one or more bacteriophages, and
- determining the ability of said preparation to increase susceptibility of said cells to said antibiotic by in vitro antibiotic testing in the absence of bacteriophages using samples of bacterial cells from said infection or from another infection by the same or a comparable bacterial strain of the same species subject to identical exposure to said bacteriophage preparation,
- wherein said in vitro antibiotic testing is carried out both before and after the exposure to said bacteriophage preparation, and
- said infection is a Pseudomonas aeruginosa infection.
1 more element
A method to treat a bacterial infection in a human or animal, comprising:
- testing bacteria from the bacterial infection for susceptibility to an antibiotic, before the bacteria are exposed to a bacteriophage preparation,
- administering the bacteriophage preparation to the human or animal, to expose the bacteria in the bacterial infection, to the bacteriophage preparation,
- testing the bacteria from the bacterial infection for susceptibility to the antibiotic, after the bacteria are exposed to the bacteriophage preparation, and
- administering the antibiotic to the human or animal, after administering the bacteriophage preparation,
- wherein the bacteriophage preparation comprises one or more bacteriophages,
- susceptibility of the bacteria to the antibiotic after the bacteria are exposed to the bacteriophage preparation, is greater than susceptibility of the bacteria to the antibiotic before the bacteria are exposed to the bacteriophage preparation, and
- the bacteria are Pseudomonas aeruginosa.
4 more elements
Dependencies are inferred from the claim text.