Back to results
US 8,475,784 B2Granted
IL-21 variants
AssigneeNovo Nordisk A/S
InventorsSiv Annegrethe Hjorth, Kent Bondensgaard, Dennis Madsen
Life of this patent
Estimating the term…
Abstract
IL-21 variants are provided wherein amino acids have been deleted in the region consisting of amino acid residues no. 65 to 98.
Claims6
An isolated variant IL-21 peptide comprising an amino acid sequence, which varies from SEQ ID NO:2 in that amino acid residues 83-88 in SEQ ID NO:2 are deleted, and amino acid residues at positions 77-79, 81 and 91 in SEQ ID NO:
- 2 are replaced by non-conservative amino acid residues, and wherein amino acid residues at positions 82, 89 and 90 are either deleted or replaced by non-conservative amino acid residues, wherein the variant binds to the human IL-21 receptor.
Dependencies are inferred from the claim text.