Method for treating surfaces with copolymers

A cytotoxic or cell-adhesion statistical copolymer containing at least a monomer unit of type A and at least a monomer unit of type B, wherein monomer unit of type A contains at least a reactive site able to attach to a substrate or a surface containing labile hydrogen atoms by covalent bonds, wherein:

• the monomer unit of type B contains at least one molecule able to confer antimicrobial, antiviricidal and/or antifungicidal properties or cell-adhesion properties to said substrate or said surface, and the reactive site for promoting the attachment of said copolymer to a substrate is included in monomer of type A under the following formula
• wherein
• □ means the link to monomer A
• m is 0 or 1,
• X1 represents an amine, an amide or a ketone function, an oligoethylene glycol, an arylene group, a (C1-C6)alkylarylene, or a (C1-C8)alkylene which may be interrupted by any one of an amine, an amide or a ketone function, one of the carbon atom in the (C1-C8)alkylene being optionally replaced by a quaternary ammonium, a quaternary phosphonium a (C1-C4)alkylpyridinium, a (C1-C4)alkylimidazolium or a guanidinium group, at least one of R1, R2 and R3 is able to react with an hydroxyl, a thiol or an amine group, and the other one or two radicals chosen among R1, R2 and R3 independently represent a (C1-C4)alkoxy, or any one of the group R1, R2 and R3 is a group showing a character of leaving group or alternatively
• represents a part of monomer unit containing a 5- or 6-membered saturated ring containing a quaternary ammonium.

A cytotoxic or cell-adhesion statistical copolymer containing at least a monomer unit of type A and at least a monomer unit of type B, the monomer of unit type B comprising a quaternary ammonium group, a quaternary phosphonium group, a guanidinium group, or an aminopenicillanic acid, wherein:

• the monomer unit of type A contains at least a reactive site able to attach to a substrate or a surface containing labile hydrogen atoms by covalent bonds and in that monomer unit of type B contains at least one molecule able to confer antimicrobial, antiviricidal and/or antifungicidal properties or cell-adhesion properties to said substrate or said surface, and the reactive site for promoting the attachment of said copolymer to a substrate is included in monomer of type A under the following formula
• wherein
• □ means the link to monomer A
• m is 0 or 1,
• X1 represents an amine, an amide or a ketone function, an oligoethylene glycol, an arylene group, a (C1-C6)alkylarylene, or a (C1-C8)alkylene which may be interrupted by any one of an amine, an amide or a ketone function, one of the carbon atom in the (C1-C8)alkylene being optionally replaced by a quaternary ammonium, a quaternary phosphonium a (C1-C4)alkylpyridinium, a (C1-C4)alkylimidazolium or a guanidinium group,
• at least one of R1, R2 and R3 is able to react with an hydroxyl, a thiol or an amine group, and the other one or two radicals chosen among R1, R2 and R3 independently represent a (C1-C4)alkoxy, or any one of the group R1, R2 and R3 is a group showing a character of leaving group or alternatively
• represents a part of monomer unit containing a 5- or 6-membered saturated ring containing a quaternary ammonium.