Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis

A composition comprising a compound according to Formula I:

• wherein,
• R1 is H or alkyl;
• R2 is H, OH, O-alkyl, amino, O-heterocyc, O-aryl, O—Ac, O—PO3, O—SO3, OSO2NH2 or O-substituted alkyl wherein said substitution is halo, aryl, or heteroaryl;
• R3 is OH, O—CH2Aryl, O—CH2heteroaryl, O-alkylaryl, or O-acyl;
• R4 is H, Alkyl, CH2Aryl, substituted alkyl, OH, O-alkyl, O-aryl, OCH2Aryl, OCH2Heteroaryl, O-Acyl, OPO3, OSO3, or OSO2NH2;
• R5 is H, Oxo, aryl, hydroxyl, alkyl, or O-alkyl;
• R6 is H;
• R7 is H, Acyl, alkyl, O-alkyl, substituted alkyl wherein said substitution is hydroxyl or sulfamoyl, or O-substituted alkyl wherein said substitution is O—PO3 or OSO3;
• R8 is H;
• and
• X is O, N, or S;
• and wherein if R3 is OH or O-acyl then R7 is Acyl, alkyl, or substituted alkyl wherein said substitution is hydroxyl.