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US 8,475,772 B2Granted
Peptide-based oral care surface reagents for personal care
AssigneeE. I. Du Pont de Nemours and Company
InventorsXueying Huang, John P. O'Brien, Hong Wang
Life of this patent
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Abstract
Peptides have been identified that bind to tooth enamel. Compositions and methods comprising peptide-based oral care reagents having at least one tooth enamel-binding peptide and an oral care benefit agent are provided to adhere the benefit agent to the oral surface.
Claims16
A tooth enamel-binding peptide having an amino acid sequence SEQ ID NO:
- 145.
A diblock, peptide-based oral care reagent having the general structure (OBP)n-OBA, wherein
- a) OBP is an oral cavity surface-binding peptide;
- b) OBA is an oral care benefit agent;
- and
- c) n ranges from 1 to about 10,000 wherein said oral cavity surface-binding peptide is a tooth-binding peptide having affinity for tooth enamel;
- wherein said tooth-binding peptide is from about 7 to about 25 amino acids and has a binding affinity, measured as MB50, equal to or less than 10−5 M.
2 more elements
A triblock, peptide-based oral care reagent having the general structure [(OBP)m-S]n-OBA, wherein
- a) OBP is an oral cavity surface-binding peptide;
- b) OBA is an oral care benefit agent;
- c) S is a spacer;
- d) m ranges from 1 to about 50;
- and
- e) n ranges from 1 to about 10,000 wherein said oral cavity surface-binding peptide is a tooth-binding peptide having affinity for tooth enamel;
- wherein said tooth-binding peptide is from about 7 to about 25 amino acids and has a binding affinity, measured as MB50, equal to or less than 10−5 M.
4 more elements
Dependencies are inferred from the claim text.