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US 8,475,770 B2Granted
Foamable suspension gel
AssigneeStiefel Research Australia Pty Ltd
InventorsAlbert Zorko Abram, Lilian Fuchshuber
Life of this patent
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Abstract
The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.
Claims19
An aqueous foamable suspension gel in a pressurized container, comprising:
- an aqueous phase comprising water;
- from about 1% to about 8% w/w based on the total weight of the gel of benzoyl peroxide suspended in the aqueous phase;
- from about 0.025% to about 2% w/w based on the total weight of the gel of a retinoid;
- a thickening agent in an amount sufficient to result in a foamable suspension gel having a viscosity of about 1,000 to about 20,000 centipoise at 25° C.;
- and
- an aerosol propellant;
- wherein the gel is oil-free and alcohol-free and forms a homogenous foam when dispensed from the pressurized container.
4 more elements
An aqueous foamable suspension gel in a pressurized container, comprising:
- an aqueous phase comprising water;
- from about 1% to about 8% w/w based on the total weight of the gel of benzoyl peroxide suspended in the aqueous phase;
- from about 0.025% to about 2% w/w based on the total weight of the gel of a retinoid;
- one or more thickening agents;
- and
- an aerosol propellant;
- wherein the gel is oil-free and alcohol-free, has a viscosity of about 5,000 to about 15,000 centipoise (cP) at 25° C., and forms a homogenous foam when dispensed from the pressurized container.
4 more elements
An aqueous foamable suspension gel in a pressurized container, comprising:
- an aqueous phase comprising water;
- from about 1% to about 8% w/w based on the total weight of the gel benzoyl peroxide suspended in the aqueous phase;
- from about 0.025% to about 2% w/w based on the total weight of the gel of a retinoid;
- one or more thickening agents;
- optionally one or more excipients selected from the group consisting of a dispersing/wetting agent, a pH-adjusting, a surfactant, a sunfilter, an antioxidant, an additional foaming agent, a chelating/sequestering agent, a coloring agent and a preservative;
- and
- an aerosol propellant;
- wherein the gel is oil-free and alcohol-free, has a viscosity of about 5,000 to about 15,000 centipoise (cP) at 25° C., and forms a homogenous foam when dispensed from the pressurized container.
5 more elements
Dependencies are inferred from the claim text.