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US 8,475,340 B2Granted
Hypoxic conditioning in patients with exercise limiting conditions
AssigneeMontefiore Medical Center
InventorSimon Maybaum
Life of this patent
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AssigneeMontefiore Medical Center
InventorSimon Maybaum
Estimating the term…
Patients having exercise limiting conditions and those at risk of developing such conditions are exposed to a regimen of hypoxic conditions that simulate various altitude conditions. The exposure is of a temporary nature, being from a few hours to most of a day or night in any one day and repeated on a personally worked out regimen of from a series of consecutive days to a regular number of “on” and “off” days, to a random number of days. An alternate regimen is such exposure for a few minutes at a time followed by normoxic rest period of a few minutes, with the cycle repeated multiple times over the course of a treatment session. The conditioning treatment strengthens the cardiac tissue and skeletal muscle and the results extend beyond the treatment periods whereby the patient's condition is substantially improved.
A method of treatment of a patient having a condition which limits exercise, said condition being selected from those conditions involving cardiac tissue, said treatment comprising administering to said patient an exercise limiting alleviating effective amount of normobaric hypoxic conditions (hypoxic treatment) said hypoxic conditions being extended hypoxic conditions for at least 1 hour per day without intermittent normoxic conditions (EHT), said treatment being for a treatment cycle of at least 1 day out of not more than 22 days per treatment cycle, said hypoxic conditions being an atmosphere having less than 20.9% oxygen content, said hypoxic conditions being administered for a time period of not more than a period equal to a day or a night in any one session, whereby said patient has fewer limits on exercise due to said condition after such administration than prior to said administration.
A method of preventing congestive heart failure in a patient at risk thereof comprising administering to said patient an effective amount of normobaric hypoxic conditions (hypoxic treatment), said hypoxic conditions being extended hypoxic conditions for at least 1 hour per day without intermittent normoxic conditions (EHT), said treatment being for a treatment cycle of at least 1 day out of not more than 22 days per treatment cycle, said hypoxic conditions being an atmosphere having less than 20.9% oxygen content, said hypoxic conditions being administered for a time period of not more than a period equal to a day or a night in any one session, whereby said patient has a lesser risk of congestive heart failure after such administration than prior to said administration.
A method of improving cardio-pulmonary function in a patient suffering from or at risk of congestive heart failure, ventricular failure, angina, systolic heart failure, or diastolic heart failure comprising administering to said patient to a regimen of normobaric hypoxic conditions (hypoxic treatment), said hypoxic conditions being extended hypoxic conditions for at least 1 hour per day without intermittent normoxic conditions (EHT), said treatment being for a treatment cycle of at least 1 day out of not more than 22 days per treatment cycle, said hypoxic conditions being an atmosphere having less than 20.9% oxygen content, said hypoxic conditions being administered for a time period of not more than a period equal to a day or a night in any one session, whereby said patient has improved cardio-pulmonary function after such administration than prior to said administration.
Dependencies are inferred from the claim text.