Ionic silicone hydrogels having improved hydrolytic stability
AssigneeJohnson & Johnson Vision Care, Inc.
InventorsOsman Rathore, Zohra Fadli, Mark Lada, James D. Ford, Azaam Alli, Yongcheng Li
Life of this patent
Estimating the term…
Abstract
The present invention relates to ionic silicone hydrogel polymers displaying improved thermal stability. More specifically, the present invention relates to a polymer formed from reactive components comprising at least one silicone component and at least one ionic component comprising at least one anionic group. The polymers of the present invention display good thermal stability and desirable protein uptake.
Claims50
A polymer formed from reactive components comprising at least one silicone component comprising at least one trimethylsiloxy silyl group and at least one ionic component in an amount from about 0,05 to about 0.08 weight %;
- comprising at least one anionic group wherein said silicone component and said ionic component are present in said polymer in molar concentrations providing a stability product less than about 0.0006.
A polymer formed from reactive components comprising about 0.1 to about 0.9 weight % of at least one anionic component and at least one silicone component selected from the group consisting of reactive polydialkylsiloxane selected from compounds of Formula I:
- where b=2 to 20;
- terminal R1 are independently selected from monovalent groups comprising at least one ethylenically unsaturated moiety, monovalent alkyl group having 2 to 16 carbon atoms, provided that one terminal R1 comprises an ethylenically unsaturated moiety, and the remaining R1 are selected from monovalent alkyl groups having 1 to 16 carbon atoms;
- wherein all silicone componets are free of timethyl silyl groups.
A contact lens formed by polymerizing components comprising at least one silicone component and at least one ionic component wherein said ionic component is present in said polymer in concentration less than 0.8 wt %, and wherein at least one of said at least one silicone components comprises at least one trimethylsilyl group, said silicone component and said ionic component are present in said polymer in molar concentrations providing a stability product less than about 0.0006;
- and wherein said contact lens absorbs at least about 10 μg lysozyme, less than about 5 μg lipocalin and wherein at least about 50% of all proteins absorbed in or on said contact lens are in native form.
A contact lens formed by polymerizing components comprising at least one silicone component and at least one ionic component comprising at least one carboxylic acid group in molar concentrations up to about 9.3 mmol/100 gm and wherein at least one of said at least one silicone components comprise at least one trimethylsilyl group, said silicone component and said ionic component are present in said polymer in molar concentrations providing a stability product less than about 0.0006;
- and wherein said contact lens absorbs at least about 10 μg lysozyme, less than about 5 μg lipocalin and wherein at least about 50% of proteins absorbed in or on said contact lens are in native form.
Dependencies are inferred from the claim text.