Method for removing antiplatelet agent and anticoagulant from a platelet composition by diafiltration
AssigneeBiovec Transfusion, LLC
InventorLakshman R. Sehgal
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Abstract
The present invention relates to methods for removing antiplatelet agents and anticoagulants from a platelet preparation. In one embodiment, the method includes the step of flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. In another embodiment, the method includes the step of passing the platelet preparation through porous material that specifically binds to the antiplatelet agents and anticoagulants.
Claims7
A method for removing antiplatelet agents and anticoagulants from a platelet preparation using diafiltration, comprising:
- circulating a platelet preparation comprising platelets, a short-to-ultra short acting antiplatelet agent comprising a short-to-ultrashort GPIIb/IIIA inhibitor, and a short-to-ultra short acting anticoagulant comprising a short-to-ultrashort acting factor Xa inhibitor through a hollow fiber membrane capable of separating the antiplatelet agent and the anticoagulant from the platelets,
- wherein a diafiltration buffer is added to the platelet preparation during circulation to maintain a constant volume of the platelet preparation.
Dependencies are inferred from the claim text.