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US 8,470,310 B2Granted
Simian adenoviruses SAdV-36, -42.1, -42.2, and -44 and uses thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsSoumitra Roy, James M. Wilson, Luc H. Vandenberghe
Life of this patent
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Abstract
A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.
Claims17
A recombinant adenovirus having a capsid comprising:
- (a) a hexon protein of Simian Adenovirus 42.1 (SAdV-42.1), amino acids 1 to 957 of SEQ ID NO:43;
- a penton protein of SAdV-42.1, amino acids 1 to 581 of SEQ ID NO:38;
- and a fiber protein of SAdV-42.1, amino acids 1 to 577 of SEQ ID NO:52;
- (b) a hexon protein of SAdV-42.2, amino acids 1 to 957 of SEQ ID NO:74;
- a penton protein of SAdV-42.2, amino acids 1 to 586 of SEQ ID NO:69;
- and a fiber protein of SAdV-42.2, amino acids 1 to 595 of SEQ ID NO:83;
- or
- (c) a hexon protein of SAdV-44, amino acids 1 to 962 of SEQ ID NO:105;
- a penton protein of SAdV-44, amino acids 1 to 581 of SEQ ID NO:100;
- and a fiber protein of SAdV-44, amino acids 1 to 560 of SEQ ID NO:121;
- said capsid encapsidating a heterologous nucleic acid molecule carrying a gene sequence operably linked to expression control sequences which direct transcription, translation, or expression in a host cell.
8 more elements
Dependencies are inferred from the claim text.