Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof
AssigneeArdea Biosciences, Inc.
InventorStuart Dimock
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Abstract
Disclosed herein, in certain embodiments, is a crystalline polymorph form A of N—(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide. Further disclosed herein, in certain embodiments, are pharmaceutical compositions comprising the crystalline polymorph form A of N—(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide.
Claims20
A pharmaceutical combination, comprising a N—(S)-(3,4-difluoro-2- (2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1- (2,3-dihydroxypropyl) cyclopropane-1-sulfonamide and a compound selected from the group consisting of lipid or protein kinase targeting agents, apoptotic pathway agonists, multikinase inhibitors and sorafenib.
Dependencies are inferred from the claim text.