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US 8,466,260 B2Granted
Anti-FcRH5 antibodies and immunoconjugates and methods of use
AssigneeGenentech, Inc.
InventorsKristi Elkins, Andrew Polson, Allen Ebens, Camelia Adams, Bing Zheng, Jagath R. Junutula, Jo-Anne Hongo, Yan Wu
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Abstract
The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
Claims49
An isolated monoclonal anti-FcRH5 antibody comprising:
- (a) a light chain variable domain comprising:
- (i) HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 26;
- (ii) HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 27;
- and
- (iii) HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 28;
- and
- (b) a heavy chain variable domain comprising:
- (i) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 35;
- (ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 36;
- and
- (iii) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 37.
14 more elements
An immunoconjugate having the formula Ab-(L-D)p, wherein:
- (a) Ab is an antibody, wherein the antibody is an isolated monoclonal anti-FcRH5 antibody comprising:
- (i) a light chain variable domain comprising:
- a. HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 26;
- b. HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 27;
- and
- c. HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 28;
- and
- (ii) a heavy chain variable domain comprising:
- a. HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 35;
- b. HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 36;
- and
- c. HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 37;
- (b) L is a linker, wherein the linker is MC-VC-PAB;
- (c) D is a drug moiety, wherein the drug moiety is MMAE;
- and
- (d) p is 1 to 8.
19 more elements
Dependencies are inferred from the claim text.