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US 8,466,118 B2Granted
Modulation of blood brain barrier protein expression
AssigneeSaint Louis University
InventorsWilliam A. Banks, Vijaya B. Kumar, Thomas Darling, Robert Clayton
Life of this patent
Estimating the term…
Abstract
There are disclosed agents that inhibit Blood Brain Barrier Proteins (BBBP). Such agents are useful in controlling agents entering and exiting the CNS. This allows for drugs to be more effective and/or allowing side effects of the drugs to be lowered.
Claims3
A method of inhibiting P-glycoprotein in a patient comprising administering to said patient a phosphorothioate antisense molecule that hybridizes to a P-glycoprotein nucleic acid, wherein said antisense molecule is selected from the group consisting of SEQ ID NOS:
- 17, 18, 19 20, 21, 35, 36 37, 38, 39 and 40.
Dependencies are inferred from the claim text.