# US 8,465,973 B2 · Topical compositions containing phosphorylated polyphenols

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- Number: US 8,465,973 B2
- Document ID: US8465973B2
- Status: Granted
- Kind: B2
- Application number: 12/481,156
- Filed: 2009-06-09
- Published: 2009-10-01
- Granted: 2013-06-18
- Earliest claimed: 2009-06-09
- Assignees: Estee Lauder Coordination Center N.V.; Ajinomoto Omnichem S.A.
- Applicants: Lieve Declercq; Hugo Corstjens; Daniël Maes; Willy Van Brussel; Geert Schelkens
- Inventors: Lieve Declercq; Hugo Corstjens; Daniël Maes; Willy Van Brussel; Geert Schelkens
- Web page: https://patentgrep.com/patent/US8465973B2

## CPC

- A61K 36/00: Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines {(antigens from pollen A61K39/36)}
- A61K 31/66: Phosphorus compounds
- A61K 36/87: Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/06: Antipsoriatics
- A61P 17/08: Antiseborrheics
- A61P 17/10: Anti-acne agents
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides topical compositions containing phosphorylated polyphenols in combination with a topically acceptable carrier. The compositions of the invention provide a means for delayed delivery of the polyphenol to keratinous tissues, such as skin, hair and nails, with enzymes of the keratinous tissue dephosphorylating the polyphenol, and returning it to its native active form. The compositions are particularly useful in the regulation of skin conditions. the phosphorylated stilbene is a phosphorylated resveratrol or a phosphorylated resveratrol derivative.

## Claims

### Claim 1

A topical composition for application to a keratinous tissue, comprising at least one water soluble phosphorylated stilbene selected from the group consisting of resveratrol monophosphate, resveratrol diphosphate, resveratrol triphosphate, mixtures thereof, and metal salts thereof, in combination with a cosmetically or pharmaceutically acceptable carrier.

### Claim 2 (depends on 1)

The composition of claim 1 in which the phosphorylated stilbene is a metal salt of resveratrol monophosphate, resveratrol diphosphate, resveratrol triphosphate or mixtures thereof.

### Claim 3 (depends on 1)

The composition of claim 1 in which the phosphorylated stilbene is resveratrol triphosphate.

### Claim 4 (depends on 1)

The composition of claim 1 which comprises at least one skin benefit agent selected from the group consisting of astringents, antioxidants, free radical scavengers, anti-acne agents, antimicrobial agents, antifungal agents, chelating agents, anti-aging agents, anti-wrinkle agents, analgesics, skin lightening agents, skin conditioning agents, anti-irritants, anti-inflammatories, anti-cellulite agents, humectants, emollients, organic sunscreens, inorganic sun protecting agents, chemical exfoliating agents, physical exfoliating agent, self-tanning agents, biologically active peptides; and mixtures thereof.

### Claim 5 (depends on 1)

The topical composition according to claim 1, wherein said water soluble phosphorylated stilbene is selected from the group consisting of resveratrol diphosphate, resveratrol triphosphate, and metal salts thereof.

### Claim 6 (depends on 1)

A method of regulating skin condition comprising applying to the skin of a subject in need thereof the topical composition according to claim 1.

### Claim 7 (depends on 6)

The method of claim 6 in which the skin condition to be treated is selected from the group consisting of eczema, seborrhea, psoriasis, xerosis, neoplastic growths, dermatitis, folliculitis, rosacea and acne.

### Claim 8 (depends on 6)

The method of claim 6 in which the skin condition to be treated is one or more signs of skin aging.

### Claim 9 (depends on 6)

The method of claim 6 in which the phosphorylated stilbene is resveratrol triphosphate.

### Claim 10 (depends on 1)

A method of regulating the effects of reactive oxygen species on a cell of a keratinous tissue, said method comprises applying to the cell of a subject in need thereof the topical composition according to claim 1.