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US 8,465,964 B2Granted
Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
AssigneeButamax (TM) Advanced Biofules LLC
InventorLarry Cameron Anthony
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Abstract
Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase.
Claims10
A recombinant yeast host cell which produces isobutanol and comprises mitochondria which is substantially devoid of threonine deaminase activity.
Dependencies are inferred from the claim text.