# US 8,465,962 B2 · Microorganism having enhanced L-valine productivity and method for producing L-valine using the same

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- Number: US 8,465,962 B2
- Document ID: US8465962B2
- Status: Granted
- Kind: B2
- Application number: 13/310,536
- Filed: 2011-12-02
- Published: 2013-02-21
- Granted: 2013-06-18
- Earliest claimed: 2011-08-16
- Assignees: Cj Cheiljedang Corporation
- Applicants: Hye Won Kim; Ji-Hye Lee; Soo Youn Hwang; Jong Hyun Kim
- Inventors: Hye Won Kim; Ji-Hye Lee; Soo Youn Hwang; Jong Hyun Kim
- Web page: https://patentgrep.com/patent/US8465962B2

## CPC

- C12N 1/205: Bacterial isolates
- C12P 13/08: Lysine; Diaminopimelic acid; Threonine; Valine
- C12R 2001/15: Corynebacterium
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

The present invention relates to a microorganism having an enhanced L-valine productivity and a method for producing L-valine using the same. More particularly, the present invention relates to a Corynebacterium glutamicum mutant strain that has resistance to L-valine and derivatives thereof so as to have an enhanced L-valine productivity, and a method for producing L-valine using the same.

## Claims

### Claim 1

An L-valine-producing Corynebacterium glutamicum mutant strain KCCM11201P.

### Claim 2 (depends on 1)

The mutant strain KCCM11201P according to claim 1, wherein the mutant strain has resistance to α-aminobutyric acid (ABA), α-hydroxyvaline (AHV), thiazole alanine (TA) and norvaline (NV).

### Claim 3 (depends on 1)

A method for producing L-valine, comprising culturing KCCM11201P of claim 1 in a culture medium to produce L-valine, and recovering L-valine from the culture medium.

### Claim 4 (depends on 3)

The method according to claim 3, wherein the cultivation is performed at a temperature of 20 to 45° C. under aerobic condition for 10 to 160 hours.