# US 8,465,835 B2 · Capsules

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- Number: US 8,465,835 B2
- Document ID: US8465835B2
- Status: Granted
- Kind: B2
- Application number: 12/438,430
- Filed: 2007-08-31
- Published: 2010-01-07
- Granted: 2013-06-18
- Earliest claimed: 2006-09-12
- Assignees: Givaudan SA
- Applicants: Robert Guisinger
- Inventors: Robert Guisinger
- Web page: https://patentgrep.com/patent/US8465835B2

## CPC

- B01J 13/14: Polymerisation; cross-linking
- Y10T 428/2982: Particulate matter [e.g., sphere, flake, etc.]
- Y10T 428/2984: Microcapsule with fluid core [includes liposome]
- Y10T 428/2985: Solid-walled microcapsule from synthetic polymer
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A method of making core-shell capsules containing a water-immiscible liquid, comprising the steps of (a) dispersing into the water-immiscible liquid a crosslinking agent that is inactive under the conditions of the dispersion; (b) emulsifying the resulting dispersion into an aqueous solution of a crosslinkable hydrocolloid; and (c) activating the crosslinking agent to cause the hydrocolloid to crosslink at the dispersion/solution interface. The method is simple and provides capsules that can be cold-loaded. The capsule material may be made of vegetable-derived materials.

## Claims

### Claim 1

A method of making core-shell capsules containing a water-immiscible liquid, comprising the steps of
(a) dispersing into the water-immiscible liquid a crosslinking agent that is inactive under the conditions of the dispersion;
(b) emulsifying the resulting dispersion into an aqueous solution of a crosslinkable hydrocolloid; and
(c) activating the crosslinking agent to cause the hydrocolloid to crosslink at the dispersion/solution interface.

### Claim 2 (depends on 1)

A method according to claim 1, in which the hydrocolloid is derived from a vegetable source.

### Claim 3 (depends on 2)

A method according to claim 2, in which the hydrocolloid is at least one of a food-grade alginate salt, pectin, curdlan gum or gellan gum.

### Claim 4 (depends on 1)

A method according to claim 1, in which the water-immiscible liquid to be encapsulated is a flavor oil or pharmaceutical present during the process of preparing the capsules.

### Claim 5 (depends on 1)

A method according to claim 1, in which the water-immiscible liquid is water-immiscible solvent, the capsules are made as blank capsules and are loaded with a further water-immiscible liquid to be encapsulated in a subsequent step.

### Claim 6 (depends on 1)

Liquid-containing core-shell capsules prepared according to claim 1.

### Claim 7 (depends on 1)

Application comprising an application base and loaded core-shell capsules prepared according to claim 1.

### Claim 8 (depends on 7)

The application according to claim 7, in which the hydrocolloid is derived from a vegetable source.

### Claim 9 (depends on 7)

The application according to claim 7, in which the hydrocolloid is at least one of a food-grade alginate salt, pectin, curdlan gum or gellan gum.

### Claim 10 (depends on 7)

The application according to claim 7, in which the water-immiscible liquid comprises a flavor oil.

### Claim 11 (depends on 7)

The application according to claim 7, in which the water-immiscible liquid comprises a pharmaceutical.

### Claim 12 (depends on 6)

The core-shell capsules according to claim 6, in which the hydrocolloid is derived from a vegetable source.

### Claim 13 (depends on 6)

The core-shell capsules according to claim 6, in which the hydrocolloid is at least one of a food-grade alginate salt, pectin, curdlan gum or gellan gum.

### Claim 14 (depends on 6)

The core-shell capsules according to claim 6, in which the water-immiscible liquid comprises a flavor oil.

### Claim 15 (depends on 6)

The core-shell capsules according to claim 6, in which the water-immiscible liquid comprises a pharmaceutical.