# US 8,465,790 B2 · Metallic implant and process for treating a metallic implant

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- Number: US 8,465,790 B2
- Document ID: US8465790B2
- Status: Granted
- Kind: B2
- Application number: 11/840,657
- Filed: 2007-08-17
- Published: 2008-01-17
- Granted: 2013-06-18
- Earliest claimed: 1993-12-20
- Assignees: AstraZeneca AB
- Applicants: Jan Eirik Ellingsen; Gunnar Rölla
- Inventors: Jan Eirik Ellingsen; Gunnar Rölla
- Web page: https://patentgrep.com/patent/US8465790B2

## CPC

- A61K 33/16: Fluorine compounds
- A61L 27/06: Titanium or titanium alloys
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61F 2310/00023: Titanium or titanium-based alloys, e.g. Ti-Ni alloys
- A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L 2300/106: Halogens or compounds thereof, e.g. iodine, chlorite
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

A process for treating a metallic implant consisting essentially of treating the metallic implant with a solution of hydrofluoric acid, which solution has a pH between 1.6 and 3.0.

## Claims

### Claim 1

A process of treating a bone implant of titanium or a titanium alloy consisting essentially of:
treating the metallic bone implant using an aqueous solution of hydrofluoric acid at room temperature for a period of between 10 seconds and 2 minutes in which the concentration of hydrofluoric acid is about 0.2% to about 0.5%.

### Claim 2 (depends on 1)

The process of claim 1 in which the treatment is carried out for a period of 10 to 50 seconds.

### Claim 3 (depends on 1)

A process as claimed in claim 1 in which the concentration of hydrofluoric acid is approximately 0.2%.

### Claim 4 (depends on 1)

A process as claimed in claim 1 in which the treatment is carried out for a period of about 2 minutes.

### Claim 5 (depends on 1)

A process as claimed in claim 1, in which the surface of the metallic bone implant after the treatment with the hydrofluoric acid solution has substantially the same morphology as the surface of the implant before said treatment.

### Claim 6 (depends on 1)

A process as claimed in claim 1, wherein said metallic bone implant of titanium or a titanium alloy has a surface layer constituted by a metallic oxide.

### Claim 7 (depends on 1)

A process as claimed in claim 1, wherein said metallic bone implant is constituted by titanium or a titanium alloy, and said metallic oxide is a titanium oxide.